DNA methylation is an epigenetic modification of DNA. The attachment of methyl groups can switch the gene on or off and lead to a change in the way the DNA interacts with other proteins and consequently affect cell function. Healthy cells have developmentally prescribed patterns of DNA methylation throughout their genome that are universally disrupted in human cancers. As such, detection of DNA methylation of several frequently aberrantly methylated regions can provide higher sensitivity over a single or few mutation markers for cancer identification.
Our DNA methylation markers can be used for:
- Diagnosis of early malignancy
- Monitoring therapeutic response
- Monitoring disease recurrence